# Sources: Magnesium, NMDA Receptors and Learning Back to [[Topics/Magnesium, NMDA Receptors and Learning/Magnesium, NMDA Receptors and Learning|hub]]. Bibliographic details were checked against Europe PMC, PubMed or the publisher on Oct 25, 2026, except the full Slutsky author list and the Ma et al. paper, which were not checked. | Source | What it shows | Used for | |---|---|---| | Nowak L, Bregestovski P, Ascher P, Herbet A, Prochiantz A. "Magnesium gates glutamate-activated channels in mouse central neurones." *Nature* 1984;307:462–465. [doi:10.1038/307462a0](https://doi.org/10.1038/307462a0) | Discovery of the Mg²⁺ gating of NMDA-type channels | Claim 1 | | Mayer ML, Westbrook GL, Guthrie PB. "Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones." *Nature* 1984;309:261–263. [doi:10.1038/309261a0](https://doi.org/10.1038/309261a0) | Independent discovery of the voltage-dependent block | Claim 1 | | Johnson JW, Ascher P. "Glycine potentiates the NMDA response in cultured mouse brain neurons." *Nature* 1987;325:529–531. [doi:10.1038/325529a0](https://doi.org/10.1038/325529a0) | Glycine co-agonist requirement (omitted by the post) | Claim 3 | | Jahr CE, Stevens CF. "Voltage dependence of NMDA-activated macroscopic conductances predicted by single-channel kinetics." *J Neurosci* 1990;10(9):3178–3182. [doi:10.1523/jneurosci.10-09-03178.1990](https://doi.org/10.1523/jneurosci.10-09-03178.1990) · [PubMed 1697902](https://pubmed.ncbi.nlm.nih.gov/1697902/) | Quantitative model of block vs voltage and [Mg²⁺] | **Cited by the post** | | Lisman J, Schulman H, Cline H. "The molecular basis of CaMKII function in synaptic and behavioural memory." *Nat Rev Neurosci* 2002;3:175–190. [doi:10.1038/nrn753](https://doi.org/10.1038/nrn753) | Ca²⁺ → CaMKII → LTP | Claims 2, 7 | | Slutsky I, …, Liu G. "Enhancement of Learning and Memory by Elevating Brain Magnesium." *Neuron* 2010;65(2):165–177. [doi:10.1016/j.neuron.2009.12.026](https://doi.org/10.1016/j.neuron.2009.12.026) | Raising brain Mg²⁺ with MgT improved memory and plasticity in rats; IV Mg raises human CSF Mg only 10–19% | Context | | Boyle NB, Lawton C, Dye L. "The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review." *Nutrients* 2017;9(5):429. [doi:10.3390/nu9050429](https://doi.org/10.3390/nu9050429) | 18 studies; "suggestive" benefit in anxiety-vulnerable samples; evidence quality "poor" | Claim 11 | | Hou H, Wang L, Fu T, Papasergi M, Yule DI, Xia H. "Magnesium Acts as a Second Messenger in the Regulation of NMDA Receptor-Mediated CREB Signaling in Neurons." *Mol Neurobiol* 2020 (pub. Mar 25, 2020). [doi:10.1007/s12035-020-01871-z](https://doi.org/10.1007/s12035-020-01871-z) · [PMC8202957](https://pmc.ncbi.nlm.nih.gov/articles/PMC8202957/) | Mg²⁺ influx through NMDARs boosts CREB via p38 MAPK (rat neurons, slices) | **Cited by the post** | | Ma et al. "Dysregulated cholesterol trafficking through ABCA1 drives neurodegeneration in Parkinson's disease." *Nat Neurosci* 2026. [doi:10.1038/s41593-026-02487-7](https://doi.org/10.1038/s41593-026-02487-7) | Source of @WilliamWallace's Oct 22 magnesium-citrate post (Fig. 8i,j, per his card) | Profile context; not read in full ❓ |